RapamycinFungusV1, Main, Exploration, bibRecord, 000767

RNA polymerase III limits longevity downstream of TORC1.

Identifieur interne : 000767 ( Main/Exploration ); précédent : 000766; suivant : 000768

RNA polymerase III limits longevity downstream of TORC1.

Auteurs : Danny Filer [Royaume-Uni] ; Maximillian A. Thompson [Royaume-Uni] ; Vakil Takhaveev [Pays-Bas] ; Adam J. Dobson [Royaume-Uni] ; Ilektra Kotronaki [Royaume-Uni] ; James W M. Green [Royaume-Uni] ; Matthias Heinemann [Pays-Bas] ; Jennifer M A. Tullet [Royaume-Uni] ; Nazif Alic [Royaume-Uni]

Source :

Nature [ 1476-4687 ] ; 2017.

RBID : pubmed:29186112

Descripteurs français

KwdFr :
- Aliments (MeSH), Animaux (MeSH), Biosynthèse des protéines (MeSH), Caenorhabditis elegans (effets des médicaments et des substances chimiques), Caenorhabditis elegans (enzymologie), Caenorhabditis elegans (physiologie), Cellules souches (cytologie), Cellules souches (enzymologie), Complexe-1 cible mécanistique de la rapamycine (antagonistes et inhibiteurs), Complexe-1 cible mécanistique de la rapamycine (métabolisme), Drosophila melanogaster (effets des médicaments et des substances chimiques), Drosophila melanogaster (enzymologie), Drosophila melanogaster (physiologie), Femelle (MeSH), Intestins (cytologie), Intestins (enzymologie), Longévité (effets des médicaments et des substances chimiques), Longévité (physiologie), Mâle (MeSH), RNA polymerase III (antagonistes et inhibiteurs), RNA polymerase III (déficit), RNA polymerase III (métabolisme), Saccharomyces cerevisiae (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (enzymologie), Saccharomyces cerevisiae (physiologie), Vieillissement (effets des médicaments et des substances chimiques), Vieillissement (physiologie), Évolution moléculaire (MeSH).
MESH :
- antagonistes et inhibiteurs : Complexe-1 cible mécanistique de la rapamycine, RNA polymerase III.
- cytologie : Cellules souches, Intestins.
- déficit : RNA polymerase III.
- effets des médicaments et des substances chimiques : Caenorhabditis elegans, Drosophila melanogaster, Longévité, Saccharomyces cerevisiae, Vieillissement.
- enzymologie : Caenorhabditis elegans, Cellules souches, Drosophila melanogaster, Intestins, Saccharomyces cerevisiae.
- métabolisme : Complexe-1 cible mécanistique de la rapamycine, RNA polymerase III.
- physiologie : Caenorhabditis elegans, Drosophila melanogaster, Longévité, Saccharomyces cerevisiae, Vieillissement.
- Aliments, Animaux, Biosynthèse des protéines, Femelle, Mâle, Évolution moléculaire.

English descriptors

KwdEn :
- Aging (drug effects), Aging (physiology), Animals (MeSH), Caenorhabditis elegans (drug effects), Caenorhabditis elegans (enzymology), Caenorhabditis elegans (physiology), Drosophila melanogaster (drug effects), Drosophila melanogaster (enzymology), Drosophila melanogaster (physiology), Evolution, Molecular (MeSH), Female (MeSH), Food (MeSH), Intestines (cytology), Intestines (enzymology), Longevity (drug effects), Longevity (physiology), Male (MeSH), Mechanistic Target of Rapamycin Complex 1 (antagonists & inhibitors), Mechanistic Target of Rapamycin Complex 1 (metabolism), Protein Biosynthesis (MeSH), RNA Polymerase III (antagonists & inhibitors), RNA Polymerase III (deficiency), RNA Polymerase III (metabolism), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (enzymology), Saccharomyces cerevisiae (physiology), Stem Cells (cytology), Stem Cells (enzymology).
MESH :
- chemical , antagonists & inhibitors : Mechanistic Target of Rapamycin Complex 1, RNA Polymerase III.
- cytology : Intestines, Stem Cells.
- chemical , deficiency : RNA Polymerase III.
- drug effects : Aging, Caenorhabditis elegans, Drosophila melanogaster, Longevity, Saccharomyces cerevisiae.
- enzymology : Caenorhabditis elegans, Drosophila melanogaster, Intestines, Saccharomyces cerevisiae, Stem Cells.
- chemical , metabolism : Mechanistic Target of Rapamycin Complex 1, RNA Polymerase III.
- physiology : Aging, Caenorhabditis elegans, Drosophila melanogaster, Longevity, Saccharomyces cerevisiae.
- Animals, Evolution, Molecular, Female, Food, Male, Protein Biosynthesis.

Abstract

Three distinct RNA polymerases transcribe different classes of genes in the eukaryotic nucleus. RNA polymerase (Pol) III is the essential, evolutionarily conserved enzyme that generates short, non-coding RNAs, including tRNAs and 5S rRNA. The historical focus on transcription of protein-coding genes has left the roles of Pol III in organismal physiology relatively unexplored. Target of rapamycin kinase complex 1 (TORC1) regulates Pol III activity, and is also an important determinant of longevity. This raises the possibility that Pol III is involved in ageing. Here we show that Pol III limits lifespan downstream of TORC1. We find that a reduction in Pol III extends chronological lifespan in yeast and organismal lifespan in worms and flies. Inhibiting the activity of Pol III in the gut of adult worms or flies is sufficient to extend lifespan; in flies, longevity can be achieved by Pol III inhibition specifically in intestinal stem cells. The longevity phenotype is associated with amelioration of age-related gut pathology and functional decline, dampened protein synthesis and increased tolerance of proteostatic stress. Pol III acts on lifespan downstream of TORC1, and limiting Pol III activity in the adult gut achieves the full longevity benefit of systemic TORC1 inhibition. Hence, Pol III is a pivotal mediator of this key nutrient-signalling network for longevity; the growth-promoting anabolic activity of Pol III mediates the acceleration of ageing by TORC1. The evolutionary conservation of Pol III affirms its potential as a therapeutic target.

DOI: 10.1038/nature25007
PubMed: 29186112
PubMed Central: PMC5732570

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000663
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Le document en format XML

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<term>Aging (physiology)</term>
<term>Animals (MeSH)</term>
<term>Caenorhabditis elegans (drug effects)</term>
<term>Caenorhabditis elegans (enzymology)</term>
<term>Caenorhabditis elegans (physiology)</term>
<term>Drosophila melanogaster (drug effects)</term>
<term>Drosophila melanogaster (enzymology)</term>
<term>Drosophila melanogaster (physiology)</term>
<term>Evolution, Molecular (MeSH)</term>
<term>Female (MeSH)</term>
<term>Food (MeSH)</term>
<term>Intestines (cytology)</term>
<term>Intestines (enzymology)</term>
<term>Longevity (drug effects)</term>
<term>Longevity (physiology)</term>
<term>Male (MeSH)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (antagonists & inhibitors)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (metabolism)</term>
<term>Protein Biosynthesis (MeSH)</term>
<term>RNA Polymerase III (antagonists & inhibitors)</term>
<term>RNA Polymerase III (deficiency)</term>
<term>RNA Polymerase III (metabolism)</term>
<term>Saccharomyces cerevisiae (drug effects)</term>
<term>Saccharomyces cerevisiae (enzymology)</term>
<term>Saccharomyces cerevisiae (physiology)</term>
<term>Stem Cells (cytology)</term>
<term>Stem Cells (enzymology)</term>
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<term>Animaux (MeSH)</term>
<term>Biosynthèse des protéines (MeSH)</term>
<term>Caenorhabditis elegans (effets des médicaments et des substances chimiques)</term>
<term>Caenorhabditis elegans (enzymologie)</term>
<term>Caenorhabditis elegans (physiologie)</term>
<term>Cellules souches (cytologie)</term>
<term>Cellules souches (enzymologie)</term>
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<term>Complexe-1 cible mécanistique de la rapamycine (métabolisme)</term>
<term>Drosophila melanogaster (effets des médicaments et des substances chimiques)</term>
<term>Drosophila melanogaster (enzymologie)</term>
<term>Drosophila melanogaster (physiologie)</term>
<term>Femelle (MeSH)</term>
<term>Intestins (cytologie)</term>
<term>Intestins (enzymologie)</term>
<term>Longévité (effets des médicaments et des substances chimiques)</term>
<term>Longévité (physiologie)</term>
<term>Mâle (MeSH)</term>
<term>RNA polymerase III (antagonistes et inhibiteurs)</term>
<term>RNA polymerase III (déficit)</term>
<term>RNA polymerase III (métabolisme)</term>
<term>Saccharomyces cerevisiae (effets des médicaments et des substances chimiques)</term>
<term>Saccharomyces cerevisiae (enzymologie)</term>
<term>Saccharomyces cerevisiae (physiologie)</term>
<term>Vieillissement (effets des médicaments et des substances chimiques)</term>
<term>Vieillissement (physiologie)</term>
<term>Évolution moléculaire (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Mechanistic Target of Rapamycin Complex 1</term>
<term>RNA Polymerase III</term>
</keywords>
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<term>RNA polymerase III</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules souches</term>
<term>Intestins</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Intestines</term>
<term>Stem Cells</term>
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<term>Caenorhabditis elegans</term>
<term>Drosophila melanogaster</term>
<term>Longevity</term>
<term>Saccharomyces cerevisiae</term>
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<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>RNA polymerase III</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Caenorhabditis elegans</term>
<term>Drosophila melanogaster</term>
<term>Longévité</term>
<term>Saccharomyces cerevisiae</term>
<term>Vieillissement</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Caenorhabditis elegans</term>
<term>Cellules souches</term>
<term>Drosophila melanogaster</term>
<term>Intestins</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Caenorhabditis elegans</term>
<term>Drosophila melanogaster</term>
<term>Intestines</term>
<term>Saccharomyces cerevisiae</term>
<term>Stem Cells</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Mechanistic Target of Rapamycin Complex 1</term>
<term>RNA Polymerase III</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>RNA polymerase III</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Caenorhabditis elegans</term>
<term>Drosophila melanogaster</term>
<term>Longévité</term>
<term>Saccharomyces cerevisiae</term>
<term>Vieillissement</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term>
<term>Caenorhabditis elegans</term>
<term>Drosophila melanogaster</term>
<term>Longevity</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Evolution, Molecular</term>
<term>Female</term>
<term>Food</term>
<term>Male</term>
<term>Protein Biosynthesis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Aliments</term>
<term>Animaux</term>
<term>Biosynthèse des protéines</term>
<term>Femelle</term>
<term>Mâle</term>
<term>Évolution moléculaire</term>
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<front><div type="abstract" xml:lang="en">Three distinct RNA polymerases transcribe different classes of genes in the eukaryotic nucleus. RNA polymerase (Pol) III is the essential, evolutionarily conserved enzyme that generates short, non-coding RNAs, including tRNAs and 5S rRNA. The historical focus on transcription of protein-coding genes has left the roles of Pol III in organismal physiology relatively unexplored. Target of rapamycin kinase complex 1 (TORC1) regulates Pol III activity, and is also an important determinant of longevity. This raises the possibility that Pol III is involved in ageing. Here we show that Pol III limits lifespan downstream of TORC1. We find that a reduction in Pol III extends chronological lifespan in yeast and organismal lifespan in worms and flies. Inhibiting the activity of Pol III in the gut of adult worms or flies is sufficient to extend lifespan; in flies, longevity can be achieved by Pol III inhibition specifically in intestinal stem cells. The longevity phenotype is associated with amelioration of age-related gut pathology and functional decline, dampened protein synthesis and increased tolerance of proteostatic stress. Pol III acts on lifespan downstream of TORC1, and limiting Pol III activity in the adult gut achieves the full longevity benefit of systemic TORC1 inhibition. Hence, Pol III is a pivotal mediator of this key nutrient-signalling network for longevity; the growth-promoting anabolic activity of Pol III mediates the acceleration of ageing by TORC1. The evolutionary conservation of Pol III affirms its potential as a therapeutic target.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29186112</PMID>
<DateCompleted><Year>2018</Year>
<Month>05</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-4687</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>552</Volume>
<Issue>7684</Issue>
<PubDate><Year>2017</Year>
<Month>12</Month>
<Day>14</Day>
</PubDate>
</JournalIssue>
<Title>Nature</Title>
<ISOAbbreviation>Nature</ISOAbbreviation>
</Journal>
<ArticleTitle>RNA polymerase III limits longevity downstream of TORC1.</ArticleTitle>
<Pagination><MedlinePgn>263-267</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/nature25007</ELocationID>
<Abstract><AbstractText>Three distinct RNA polymerases transcribe different classes of genes in the eukaryotic nucleus. RNA polymerase (Pol) III is the essential, evolutionarily conserved enzyme that generates short, non-coding RNAs, including tRNAs and 5S rRNA. The historical focus on transcription of protein-coding genes has left the roles of Pol III in organismal physiology relatively unexplored. Target of rapamycin kinase complex 1 (TORC1) regulates Pol III activity, and is also an important determinant of longevity. This raises the possibility that Pol III is involved in ageing. Here we show that Pol III limits lifespan downstream of TORC1. We find that a reduction in Pol III extends chronological lifespan in yeast and organismal lifespan in worms and flies. Inhibiting the activity of Pol III in the gut of adult worms or flies is sufficient to extend lifespan; in flies, longevity can be achieved by Pol III inhibition specifically in intestinal stem cells. The longevity phenotype is associated with amelioration of age-related gut pathology and functional decline, dampened protein synthesis and increased tolerance of proteostatic stress. Pol III acts on lifespan downstream of TORC1, and limiting Pol III activity in the adult gut achieves the full longevity benefit of systemic TORC1 inhibition. Hence, Pol III is a pivotal mediator of this key nutrient-signalling network for longevity; the growth-promoting anabolic activity of Pol III mediates the acceleration of ageing by TORC1. The evolutionary conservation of Pol III affirms its potential as a therapeutic target.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Filer</LastName>
<ForeName>Danny</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thompson</LastName>
<ForeName>Maximillian A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Takhaveev</LastName>
<ForeName>Vakil</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Molecular Systems Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG Groningen, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dobson</LastName>
<ForeName>Adam J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kotronaki</LastName>
<ForeName>Ilektra</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Green</LastName>
<ForeName>James W M</ForeName>
<Initials>JWM</Initials>
<AffiliationInfo><Affiliation>School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heinemann</LastName>
<ForeName>Matthias</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Molecular Systems Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG Groningen, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tullet</LastName>
<ForeName>Jennifer M A</ForeName>
<Initials>JMA</Initials>
<AffiliationInfo><Affiliation>School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alic</LastName>
<ForeName>Nazif</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>MR/L018802/1</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>P40 OD010440</GrantID>
<Acronym>OD</Acronym>
<Agency>NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>11</Month>
<Day>29</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nature</MedlineTA>
<NlmUniqueID>0410462</NlmUniqueID>
<ISSNLinking>0028-0836</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D000076222">Mechanistic Target of Rapamycin Complex 1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.7.6</RegistryNumber>
<NameOfSubstance UI="D012320">RNA Polymerase III</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Nat Rev Mol Cell Biol. 2018 Feb;19(2):74-75</RefSource>
<PMID Version="1">29235575</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Nature. 2017 Dec 14;552(7684):182-183</RefSource>
<PMID Version="1">29239369</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000375" MajorTopicYN="N">Aging</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017173" MajorTopicYN="N">Caenorhabditis elegans</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004331" MajorTopicYN="N">Drosophila melanogaster</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019143" MajorTopicYN="N">Evolution, Molecular</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005502" MajorTopicYN="N">Food</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007422" MajorTopicYN="N">Intestines</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008136" MajorTopicYN="N">Longevity</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000076222" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 1</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014176" MajorTopicYN="N">Protein Biosynthesis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012320" MajorTopicYN="N">RNA Polymerase III</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013234" MajorTopicYN="N">Stem Cells</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
</MeshHeading>
</MeshHeadingList>
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<Day>07</Day>
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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

RNA polymerase III limits longevity downstream of TORC1.

RNA polymerase III limits longevity downstream of TORC1.

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